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Structural insight into substrate binding of Acinetobacter baumannii polyphosphate-AMP phosphotransferase (PPK2), a novel drug target
Acinetobacter baumannii is an opportunistic pathogen known for high morbidity and mortality. It causes life-threatening infections, …
Lalit Kumar Gautam, Prince Sharma, Neena Capalash
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Triclosan controls pleiotropically the paper-deteriorating bacterial community in paper mill
Slime deposition on paper is a major problem confronted in paper-mills resulting in spoiled quality of the final product and huge …
Amandeep Kaur, Lalit Kumar Gautam, Sanjeev Balda, Neena Capalash, Prince Sharma
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Unraveling the molecular mechanism of l-menthol against cervical cancer based on network pharmacology, molecular docking and in vitro analysis.
Cervical cancer is a major cause of gynecological related mortalities in developing countries. Cisplatin, a potent chemotherapeutic …
Harsimran Sidhu, Lalit Kumar Gautam, Neena Capalash
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Attenuation of Acinetobacter baumannii virulence by inhibition of polyphosphate kinase 1 with repurposed drugs
Acinetobacter baumannii is clinically one of the most significant pathogens, especially in intensive care settings, because of its …
Lalit Kumar Gautam, Prince Sharma, Neena Capalash
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Attenuation of Acinetobacter baumannii virulence by inhibition of polyphosphate kinase 1 with repurposed drugs
Novel Toxin-antitoxin System Xn-mazEF from Xenorhabdus nematophila: Identification, Characterization and Functional Exploration
BACKGROUND: Xenorhabdus nematophila maintains species-specific mutual interaction with nematodes of Steinernema genus. Type II Toxin …
Jogendra Singh Nim, Mohit Yadav, Lalit Kumar Gautam, Chaitali Ghosh, Shakti Sahi, Jitendra Singh Rathore
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Novel Toxin-antitoxin System Xn-mazEF from Xenorhabdus nematophila: Identification, Characterization and Functional Exploration
Bacterial Polyphosphate Kinases Revisited: Role in Pathogenesis and Therapeutic Potential

Bacterial infections have always been an unrestrained challenge to the medical community due to the rise of multi-drug tolerant and …
Lalit Kumar Gautam, Prince Sharma, Neena Capalash
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Implication on the Function of Novel Xn-relE Toxin Structure of Xenorhabdus nematophila Using Homology Modeling

Background- Bacterial chromosomal toxin-antitoxin systems are involved in various cell functions such as stress response, promoting …
Lalit Kumar Gautam, Ragothaman M. Yennamalli, Jitendra Singh Rathore
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Functional annotation of a novel toxin-antitoxin system Xn-RelT of Xenorhabdus nematophila; a combined in silico and in vitro approach

Toxin-antitoxin (TA) complexes play an important role in stress responses and programmed cell death in bacteria. The RelB-RelE toxin …
Lalit Kumar Gautam, Mohit Yadav, Jitendra Singh Rathore
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Functional annotation of a novel toxin-antitoxin system Xn-RelT of Xenorhabdus nematophila; a combined in silico and in vitro approach
Expression, purification, and functional analysis of novel RelE operon from X. nematophila

Bacterial toxin-antitoxin (TA) complexes induce programmed cell death and also function to relieve cell from stress by various response …
Jitendra Singh Rathore, Lalit Kumar Gautam
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